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Scale-invariant structure of strongly conserved sequence in genomic intersections and alignments.

TitleScale-invariant structure of strongly conserved sequence in genomic intersections and alignments.
Publication TypeJournal Article
Year of Publication2006
AuthorsSalerno, William, Havlak Paul, and Miller Jonathan
JournalProceedings of the National Academy of Sciences of the United States of America
Volume103
Issue35
Pagination13121-5
Date Published2006 Aug 29
ISSN0027-8424
KeywordsAnimals, Base Sequence, Cluster Analysis, Conserved Sequence, Genome, Genomics, Humans, Mice, Repetitive Sequences, Nucleic Acid, Sequence Alignment
AbstractA power-law distribution of the length of perfectly conserved sequence from mouse/human whole-genome intersection and alignment is exhibited. Spatial correlations of these elements within the mouse genome are studied. It is argued that these power-law distributions and correlations are comprised in part by functional noncoding sequence and ought to be accounted for in estimating the statistical significance of apparent sequence conservation. These inter-genomic correlations of conservation are placed in the context of previously observed intra-genomic correlations, and their possible origins and consequences are discussed.
DOI10.1136/jmedgenet-2013-101558
Alternate JournalProc. Natl. Acad. Sci. U.S.A.


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