Advanced Retinal Imaging and Ocular Parameters of the Rhesus Macaque Eye.

TitleAdvanced Retinal Imaging and Ocular Parameters of the Rhesus Macaque Eye.
Publication TypeJournal Article
Year of Publication2021
AuthorsLin, KH, Tran, T, Kim, S, Park, S, J Stout, T, Chen, R, Rogers, J, Yiu, G, Thomasy, S, Moshiri, A
JournalTransl Vis Sci Technol
Date Published2021 May 03
KeywordsAnimals, Electroretinography, Intraocular Pressure, Macaca mulatta, Retina, Tomography, Optical Coherence

PURPOSE: To determine the range of normal ocular biometry and perform advanced retinal imaging and functional assessment of the rhesus macaque eye.

METHODS: We performed ocular phenotyping on rhesus macaques at the California National Primate Research Center. This process consisted of anterior and posterior segment eye examination by ophthalmologists, advanced retinal imaging, and functional retinal electrophysiology.

RESULTS: Full eye examinations were performed on 142 animals, consisting of pupillary light reflex, tonometry, external examination and photography, anterior slit lamp examination, and posterior segment examination by indirect ophthalmoscopy. Ages of the rhesus macaques ranged from 0.7 to 29 years (mean, 16.4 ± 7.5 years). Anterior segment measurements such as intraocular pressure (n = 142), corneal thickness (n = 84), lens thickness (n = 114), and axial length (n = 114) were acquired. Advanced retinal imaging in the form of fundus photography (n = 78), optical coherence tomography (n = 60), and quantitative autofluorescence (n = 44) was obtained. Electroretinography (n = 75) was used to assay retinal function. Quantitative analyses of the macular structure, retinal layer segmentation, and rod and cone photoreceptor electrical responses are reported. Quantitative assessments were made and variations between sexes were analyzed to compare with established sex changes in human eyes.

CONCLUSIONS: The rhesus macaque has an ocular structure and function very similar to that of the human eye. In particular macular structure and retinal function is very similar to humans, making this species particularly useful for the study of macular biology and development of therapies for cone photoreceptor disorders.

TRANSLATIONAL RELEVANCE: Rhesus macaques are an ideal model for future vision science studies of human eye diseases.

Alternate JournalTransl Vis Sci Technol
PubMed ID34111251
PubMed Central IDPMC8107642
Grant ListK08 EY027463 / EY / NEI NIH HHS / United States
R01 EY026045 / EY / NEI NIH HHS / United States
R21 EY031108 / EY / NEI NIH HHS / United States
P51 OD011107 / OD / NIH HHS / United States
R01 EY032238 / EY / NEI NIH HHS / United States
R01 EY016134 / EY / NEI NIH HHS / United States
U24 EY029904 / EY / NEI NIH HHS / United States

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