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Baboon Genome Project

Image: Olive baboon
Olive baboon. Image source: Stolz, Gary M. [Public domain], via Wikimedia Commons

About the Project

Diversity Panel

Image: Chacma baboon

Chacma baboon

Image source: BBC

 

Image: Guinea baboon

Guinea baboon

Image source: BBC

 

Image: Hamadrayas baboon

Hamadrayas baboon

Image source: Wisconsin National Primate Research Center

 

Image: Kinda baboon

Kinda baboon

 

Image: Yellow baboon

Yellow baboon

The BCM-HGSC is sequencing and analyzing the genome of the baboon (genus Papio). A high quality draft sequence of the reference genome has been produced from an olive baboon (Papio anubis), using read data produced by the Sanger, 454 and Illumina platforms. 

In addition to the deep sequence coverage of the reference olive baboon, BCM-HGSC has generated whole genome coverage from additional olive baboons, as well as individuals representing hamadryas (P. hamadryas), Guinea (P. papio), yellow (P. cynocephalus), chacma (P. ursinus) and kinda (P. kindae) baboons. Comparative analyses of these data are in progress and will result in a description of genomic diversity within and among species of the genus Papio. Comparisons with the human and other nonhuman primate genomes are also in progress.

Baboons are important both as a well-studied and diverse evolutionary radiation of Old World monkeys, and as laboratory primates commonly used in biomedical research. Although closely related, the species within this genus differ in social behavior, ecology, body size and other fundamental characteristics. In the laboratory, baboons are used as models of several human diseases, including cardiovascular disease, obesity, hypertension, epilepsy, infectious disease and various aspects of basic neurobiology.

The project is funded by the National Human Genome Research Institute (NHGRI).

Diversity Panel

  • Chacma baboon (P. ursinus)

  • Guinea baboon (P. papio)

  • Hamadrayas baboon (P. hamadrayas)

  • Kinda baboon (P. kindae)

  • Yellow baboon (P. cynocephalus)

  • Additional Olive baboons (P. anubis)

Genomic Resources



Related Publications

Genetic influences on response to novel objects and dimensions of personality in papio baboons., Johnson, Zachary, Brent Linda, Alvarenga Juan Carlos, Comuzzie Anthony G., Shelledy Wendy, Ramirez Stephanie, Cox Laura, Mahaney Michael C., Huang Yung-Yu, Mann John J., et al. , Behavior genetics, 2015 Mar, Volume 45, Issue 2, p.215-27, (2015) Abstract
Analysis of prostate-specific antigen transcripts in chimpanzees, cynomolgus monkeys, baboons, and african green monkeys., Mubiru, James N., Yang Alice S., Olsen Christian, Nayak Sudhir, Livi Carolina B., Dick Edward J., Owston Michael, Garcia-Forey Magdalena, Shade Robert E., and Rogers Jeffrey , PloS one, 2014, Volume 9, Issue 4, p.e94522, (2014) Abstract
Further evidence for phenotypic signatures of hybridization in descendent baboon populations., Ackermann, Rebecca R., Schroeder Lauren, Rogers Jeffrey, and Cheverud James M. , Journal of human evolution, 2014 Jun 13, (2014) Abstract
Two Novel Simian Arteriviruses in Captive and Wild Baboons (Papio spp.)., Bailey, Adam L., Lauck Michael, Sibley Samuel D., Pecotte Jerilyn, Rice Karen, Weny Geoffrey, Tumukunde Alex, Hyeroba David, Greene Justin, Correll Michael, et al. , Journal of virology, 2014 Sep 3, (2014) Abstract
Treponema pallidum infection in the wild baboons of East Africa: distribution and genetic characterization of the strains responsible., Harper, Kristin N., Fyumagwa Robert D., Hoare Richard, Wambura Philemon N., Coppenhaver Dorian H., Sapolsky Robert M., Alberts Susan C., Tung Jenny, Rogers Jeffrey, Kilewo Morris, et al. , PloS one, 2012, Volume 7, Issue 12, p.e50882, (2012) Abstract
Androgen receptor CAG repeat polymorphism in males of six non-human primate species., Mubiru, James N., Cavazos Nicole, Hemmat Peggah, Garcia-Forey Magdalena, Shade Robert E., and Rogers Jeffrey , Journal of medical primatology, 2012 Feb, Volume 41, Issue 1, p.67-70, (2012) Abstract
Genetic contributions to the midsagittal area of the corpus callosum., Phillips, Kimberley A., Rogers Jeffrey, Barrett Elizabeth A., Glahn David C., and Kochunov Peter , Twin research and human genetics : the official journal of the International Society for Twin Studies, 2012 Jun, Volume 15, Issue 3, p.315-23, (2012) Abstract
Heritability of alveolar bone loss from periodontal disease in a baboon population: a pilot study., Miley, Douglas D., Baumgartner Mark H., Cheverud James M., Roseman Charles C., Rogers Jeffrey, McLeod Dwight E., Reyes Elio, and Hildebolt Charles F. , Journal of periodontology, 2011 Apr, Volume 82, Issue 4, p.575-80, (2011) Abstract
Genetical genomics of Th1 and Th2 immune response in a baboon model of atherosclerosis risk factors., Vinson, A., Curran J. E., Johnson M. P., Dyer T. D., Moses E. K., Blangero J., Cox L. A., Rogers J., Havill L. M., VandeBerg J. L., et al. , Atherosclerosis, 2011 Aug, Volume 217, Issue 2, p.387-94, (2011) Abstract
Cortical sulcal areas in baboons (Papio hamadryas spp.) with generalized interictal epileptic discharges on scalp EEG., Szabó, C. A., Kochunov P., Knape K. D., McCoy K. J. M., Leland M. M., Lancaster J. L., Fox P. T., Williams J. T., and Rogers J. , Epilepsy research, 2011 Feb, Volume 93, Issue 2-3, p.91-5, (2011) Abstract
Kinda baboons (Papio kindae) and grayfoot chacma baboons (P. ursinus griseipes) hybridize in the Kafue river valley, Zambia., Jolly, C. J., Burrell A. S., Phillips-Conroy J. E., Bergey C., and Rogers J. , American journal of primatology, 2011 Mar, Volume 73, Issue 3, p.291-303, (2011) Abstract
Identification of a QTL for adipocyte volume and of shared genetic effects with aspartate aminotransferase., Bose, Tanushree, Voruganti Saroja V., Tejero Elizabeth M., Proffit Michael J., Cox Laura A., VandeBerg John L., Mahaney Michael C., Rogers Jeffrey, Freeland-Graves Jeanne H., Cole Shelley A., et al. , Biochemical genetics, 2010 Jun, Volume 48, Issue 5-6, p.538-47, (2010) Abstract
Genetics of primary cerebral gyrification: Heritability of length, depth and area of primary sulci in an extended pedigree of Papio baboons., Kochunov, P., Glahn D. C., Fox P. T., Lancaster J. L., Saleem K., Shelledy W., Zilles K., Thompson P. M., Coulon O., Mangin J. F., et al. , NeuroImage, 2010 Nov 15, Volume 53, Issue 3, p.1126-34, (2010) Abstract
On the genetic architecture of cortical folding and brain volume in primates., Rogers, Jeffrey, Kochunov Peter, Zilles Karl, Shelledy Wendy, Lancaster Jack, Thompson Paul, Duggirala Ravindranath, Blangero John, Fox Peter T., and Glahn David C. , NeuroImage, 2010 Nov 15, Volume 53, Issue 3, p.1103-8, (2010) Abstract
Genetic and environmental contributions to variation in baboon cranial morphology., Roseman, Charles C., Willmore Katherine E., Rogers Jeffrey, Hildebolt Charles, Sadler Brooke E., Richtsmeier Joan T., and Cheverud James M. , American journal of physical anthropology, 2010 Sep, Volume 143, Issue 1, p.1-12, (2010) Abstract
Quantitative loci regulating plasma levels of gamma glutamyl transferase and albumin and their genetic correlations with cardiovascular risk factors., Bose, Tanushree, Voruganti Saroja V., Tejero Elizabeth M., Proffitt Michael J., Cox Laura A., VandeBerg John L., Mahaney Michael C., Rogers Jeffrey, Freeland-Graves Jeanne H., Cole Shelley A., et al. , Experimental biology and medicine (Maywood, N.J.), 2009 Dec, Volume 234, Issue 12, p.vi, 1519-24, (2009) Abstract
Endometriosis is associated with progesterone resistance in the baboon (Papio anubis) oviduct: evidence based on the localization of oviductal glycoprotein 1 (OVGP1)., Wang, Chaohua, Mavrogianis Patricia A., and Fazleabas Asgerally T. , Biology of reproduction, 2009 Feb, Volume 80, Issue 2, p.272-8, (2009) Abstract
Localization of multiple pleiotropic genes for lipoprotein metabolism in baboons., Rainwater, David L., Cox Laura A., Rogers Jeffrey, VandeBerg John L., and Mahaney Michael C. , Journal of lipid research, 2009 Jul, Volume 50, Issue 7, p.1420-8, (2009) Abstract
The prolonged effect of repeated maternal glucocorticoid exposure on the maternal and fetal leptin/insulin-like growth factor axis in Papio species., Schlabritz-Loutsevitch, Natalia E., Lopez-Alvarenga Juan C., Comuzzie Anthony G., Miller Myrna M., Ford Stephen P., Li Cun, Hubbard Gene B., Ferry Robert J., and Nathanielsz Peter W. , Reproductive sciences (Thousand Oaks, Calif.), 2009 Mar, Volume 16, Issue 3, p.308-19, (2009) Abstract
Genetic variation in baboon craniofacial sexual dimorphism., Willmore, Katherine E., Roseman Charles C., Rogers Jeffrey, Richtsmeier Joan T., and Cheverud James M. , Evolution; international journal of organic evolution, 2009 Mar, Volume 63, Issue 3, p.799-806, (2009) Abstract
Comparison of Mandibular Phenotypic and Genetic Integration between Baboon and Mouse., Willmore, Katherine E., Roseman Charles C., Rogers Jeffrey, Cheverud James M., and Richtsmeier Joan T. , Evolutionary biology, 2009 Mar, Volume 36, Issue 1, p.19-36, (2009) Abstract
A pleiotropic QTL on 2p influences serum Lp-PLA2 activity and LDL cholesterol concentration in a baboon model for the genetics of atherosclerosis risk factors., Vinson, A., Mahaney M. C., Cox L. A., Rogers J., VandeBerg J. L., and Rainwater D. L. , Atherosclerosis, 2008 Feb, Volume 196, Issue 2, p.667-73, (2008) Abstract
Genotype-by-diet effects on co-variation in Lp-PLA2 activity and LDL-cholesterol concentration in baboons fed an atherogenic diet., Vinson, Amanda, Mahaney Michael C., Diego Vince P., Cox Laura A., Rogers Jeffrey, VandeBerg John L., and Rainwater David L. , Journal of lipid research, 2008 Jun, Volume 49, Issue 6, p.1295-302, (2008) Abstract
Nonhuman primates as models for studies of prostate specific antigen and prostatic diseases., Mubiru, James N., Hubbard Gene B., Dick Edward J., Furman Jaime, Troyer Dean A., and Rogers Jeffrey , The Prostate, 2008 Oct 1, Volume 68, Issue 14, p.1546-54, (2008) Abstract
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