|Olive baboon. Image source: Stolz, Gary M. [Public domain], via Wikimedia Commons|
About the Project
Image source: BBC
Image source: BBC
Image source: Wisconsin National Primate Research Center
The BCM-HGSC is sequencing and analyzing the genome of the baboon (genus Papio). A high quality draft sequence of the reference genome has been produced from an olive baboon (Papio anubis), using read data produced by the Sanger, 454 and Illumina platforms.
In addition to the deep sequence coverage of the reference olive baboon, BCM-HGSC has generated whole genome coverage from additional olive baboons, as well as individuals representing hamadryas (P. hamadryas), Guinea (P. papio), yellow (P. cynocephalus), chacma (P. ursinus) and kinda (P. kindae) baboons. Comparative analyses of these data are in progress and will result in a description of genomic diversity within and among species of the genus Papio. Comparisons with the human and other nonhuman primate genomes are also in progress.
Baboons are important both as a well-studied and diverse evolutionary radiation of Old World monkeys, and as laboratory primates commonly used in biomedical research. Although closely related, the species within this genus differ in social behavior, ecology, body size and other fundamental characteristics. In the laboratory, baboons are used as models of several human diseases, including cardiovascular disease, obesity, hypertension, epilepsy, infectious disease and various aspects of basic neurobiology.
The project is funded by the National Human Genome Research Institute (NHGRI).
Chacma baboon (P. ursinus)
Guinea baboon (P. papio)
Hamadrayas baboon (P. hamadrayas)
Kinda baboon (P. kindae)
Yellow baboon (P. cynocephalus)
Additional Olive baboons (P. anubis)