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Bovine Genome Project

About the Project

The BCM-HGSC sequenced and analyzed the bovine genome (Bos taurus). The initial bovine genome assembly and analysis and the study of cattle genetic history were published April 24, 2009. Ongoing efforts to improve the genome are centered around finishing the Y chromosome.

The source of the BABovineC library DNA was Hereford bull L1 Domino 99375, registration number 41170496. Dr. Michael MacNeil's laboratory, USDA-ARS, Miles City, MT, provided the blood. The DNA for the whole genome shotgun sequences was provided by Dr. Timothy Smith's laboratory, U.S. Meat Animal Research Center, Clay Center, NE, from white blood cells from L1 Dominette 01449, American Hereford Association registration number 42190680 (a daughter of L1 Domino 99375). A skin cell fibroblast cell line from the same animal is available from Dr. Carol Chitko-McKown's laboratory, although there is no sequence from that cell line.

Funding for this project has been provided by: the National Human Genome Research Institute (NHGRI U54 HG003273), which is part of the National Institutes of Health (NIH); the U.S. Department of Agriculture's Agricultural Research Service and Cooperative State Research, Education, and Extension Service (USDA ARS Agreement No. 5 9-0790-3-196 and CSREES Agreement No. 2004-35216-14163); the state of Texas; Genome Canada through Genome British Columbia, The Commonwealth Scientific and Industrial Research Organization of Australia (CSIRO); Agritech Investments Ltd., Dairy Insight, Inc. and AgResearch Ltd., all of New Zealand; the Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation; and the National, Texas and South Dakota Beef Check-off Funds.

Genomic Resources

Genome Assemblies

Date Released Release Name Coverage Comments
July 2012 Btau_4.6.1   Draft assembly replaced data in Btau_4.5 with high quality finished data where available.
October 2009 Btau_4.5   Draft assembly incorporating additional Whole Genome Shotgun (WGS) contigs from Btau_2.0 into Btau_4.0
April 2009 Btau_4.2 7.1x Draft assembly Btau_4.0 data replaced with high quality finished sequence where available.
October 2007 Btau_4.0 7.1x Draft assembly using (WGS) reads from small insert clones and BAC sequences. Mapped to chromosomes using refined mapping information.
August 2006 Btau_3.1 7.1x Draft assembly (WGS) reads from small insert clones and BAC sequences.
March 2005 Btau_2.0 6.2x Preliminary assembly using (WGS) reads from small insert clones and BAC end sequences.
September 2004 Btau_1.0 3x Preliminary assembly using (WGS) reads from small insert clones.

BLAST Searches

Traces are available from the NCBI Trace Archive by using the link in the sidebar or by using NCBI MegaBLAST with a same species or cross species query.

Additional Resources

Project History (next page)

Related Publications

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