Title | Clonal haematopoiesis and risk of chronic liver disease. |
Publication Type | Journal Article |
Year of Publication | 2023 |
Authors | Wong, WJ, Emdin, C, Bick, AG, Zekavat, SM, Niroula, A, Pirruccello, JP, Dichtel, L, Griffin, G, Uddin, MMesbah, Gibson, CJ, Kovalcik, V, Lin, AE, McConkey, ME, Vromman, A, Sellar, RS, Kim, PG, Agrawal, M, Weinstock, J, Long, MT, Yu, B, Banerjee, R, Nicholls, RC, Dennis, A, Kelly, M, Loh, P-R, McCarroll, S, Boerwinkle, E, Vasan, RS, Jaiswal, S, Johnson, AD, Chung, RT, Corey, K, Levy, D, Ballantyne, C, Ebert, BL, Natarajan, P |
Corporate Authors | NHLBI TOPMed Hematology Working Group |
Journal | Nature |
Volume | 616 |
Issue | 7958 |
Pagination | 747-754 |
Date Published | 2023 Apr |
ISSN | 1476-4687 |
Keywords | Animals, Clonal Hematopoiesis, Disease Progression, Disease Susceptibility, Hepatitis, Inflammation, Liver Cirrhosis, Mice, Non-alcoholic Fatty Liver Disease, Odds Ratio |
Abstract | Chronic liver disease is a major public health burden worldwide. Although different aetiologies and mechanisms of liver injury exist, progression of chronic liver disease follows a common pathway of liver inflammation, injury and fibrosis. Here we examined the association between clonal haematopoiesis of indeterminate potential (CHIP) and chronic liver disease in 214,563 individuals from 4 independent cohorts with whole-exome sequencing data (Framingham Heart Study, Atherosclerosis Risk in Communities Study, UK Biobank and Mass General Brigham Biobank). CHIP was associated with an increased risk of prevalent and incident chronic liver disease (odds ratio = 2.01, 95% confidence interval (95% CI) [1.46, 2.79]; P |
DOI | 10.1038/s41586-023-05857-4 |
Alternate Journal | Nature |
PubMed ID | 37046084 |
PubMed Central ID | PMC10405350 |
Grant List | K08 HL159346 / HL / NHLBI NIH HHS / United States F30 HL149180 / HL / NHLBI NIH HHS / United States R01 HL120393 / HL / NHLBI NIH HHS / United States G12 MD007597 / MD / NIMHD NIH HHS / United States P50 CA206963 / CA / NCI NIH HHS / United States R01 HL139865 / HL / NHLBI NIH HHS / United States S10 OD026880 / OD / NIH HHS / United States K23 DK113220 / DK / NIDDK NIH HHS / United States R01 HL142711 / HL / NHLBI NIH HHS / United States DP2 HL157540 / HL / NHLBI NIH HHS / United States DP2 ES030554 / ES / NIEHS NIH HHS / United States K08 CA263555 / CA / NCI NIH HHS / United States R01 HL117626 / HL / NHLBI NIH HHS / United States R35 CA253125 / CA / NCI NIH HHS / United States P30 DK040561 / DK / NIDDK NIH HHS / United States T32 GM136651 / GM / NIGMS NIH HHS / United States R01 DK125782 / DK / NIDDK NIH HHS / United States R01 HL148565 / HL / NHLBI NIH HHS / United States U01 HL120393 / HL / NHLBI NIH HHS / United States R01 HL082945 / HL / NHLBI NIH HHS / United States HHSN268201800001C / HL / NHLBI NIH HHS / United States P01 CA108631 / CA / NCI NIH HHS / United States R01 AI155140 / AI / NIAID NIH HHS / United States R01 AI136715 / AI / NIAID NIH HHS / United States S10 OD030463 / OD / NIH HHS / United States P01 HL132825 / HL / NHLBI NIH HHS / United States R01 HL148050 / HL / NHLBI NIH HHS / United States |
Clonal haematopoiesis and risk of chronic liver disease.
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