Clonal haematopoiesis and risk of chronic liver disease.

TitleClonal haematopoiesis and risk of chronic liver disease.
Publication TypeJournal Article
Year of Publication2023
AuthorsWong, WJ, Emdin, C, Bick, AG, Zekavat, SM, Niroula, A, Pirruccello, JP, Dichtel, L, Griffin, G, Uddin, MMesbah, Gibson, CJ, Kovalcik, V, Lin, AE, McConkey, ME, Vromman, A, Sellar, RS, Kim, PG, Agrawal, M, Weinstock, J, Long, MT, Yu, B, Banerjee, R, Nicholls, RC, Dennis, A, Kelly, M, Loh, P-R, McCarroll, S, Boerwinkle, E, Vasan, RS, Jaiswal, S, Johnson, AD, Chung, RT, Corey, K, Levy, D, Ballantyne, C, Ebert, BL, Natarajan, P
Corporate AuthorsNHLBI TOPMed Hematology Working Group
JournalNature
Volume616
Issue7958
Pagination747-754
Date Published2023 Apr
ISSN1476-4687
KeywordsAnimals, Clonal Hematopoiesis, Disease Progression, Disease Susceptibility, Hepatitis, Inflammation, Liver Cirrhosis, Mice, Non-alcoholic Fatty Liver Disease, Odds Ratio
Abstract

Chronic liver disease is a major public health burden worldwide. Although different aetiologies and mechanisms of liver injury exist, progression of chronic liver disease follows a common pathway of liver inflammation, injury and fibrosis. Here we examined the association between clonal haematopoiesis of indeterminate potential (CHIP) and chronic liver disease in 214,563 individuals from 4 independent cohorts with whole-exome sequencing data (Framingham Heart Study, Atherosclerosis Risk in Communities Study, UK Biobank and Mass General Brigham Biobank). CHIP was associated with an increased risk of prevalent and incident chronic liver disease (odds ratio = 2.01, 95% confidence interval (95% CI) [1.46, 2.79]; P 
DOI10.1038/s41586-023-05857-4
Alternate JournalNature
PubMed ID37046084
PubMed Central IDPMC10405350
Grant ListK08 HL159346 / HL / NHLBI NIH HHS / United States
F30 HL149180 / HL / NHLBI NIH HHS / United States
R01 HL120393 / HL / NHLBI NIH HHS / United States
G12 MD007597 / MD / NIMHD NIH HHS / United States
P50 CA206963 / CA / NCI NIH HHS / United States
R01 HL139865 / HL / NHLBI NIH HHS / United States
S10 OD026880 / OD / NIH HHS / United States
K23 DK113220 / DK / NIDDK NIH HHS / United States
R01 HL142711 / HL / NHLBI NIH HHS / United States
DP2 HL157540 / HL / NHLBI NIH HHS / United States
DP2 ES030554 / ES / NIEHS NIH HHS / United States
K08 CA263555 / CA / NCI NIH HHS / United States
R01 HL117626 / HL / NHLBI NIH HHS / United States
R35 CA253125 / CA / NCI NIH HHS / United States
P30 DK040561 / DK / NIDDK NIH HHS / United States
T32 GM136651 / GM / NIGMS NIH HHS / United States
R01 DK125782 / DK / NIDDK NIH HHS / United States
R01 HL148565 / HL / NHLBI NIH HHS / United States
U01 HL120393 / HL / NHLBI NIH HHS / United States
R01 HL082945 / HL / NHLBI NIH HHS / United States
HHSN268201800001C / HL / NHLBI NIH HHS / United States
P01 CA108631 / CA / NCI NIH HHS / United States
R01 AI155140 / AI / NIAID NIH HHS / United States
R01 AI136715 / AI / NIAID NIH HHS / United States
S10 OD030463 / OD / NIH HHS / United States
P01 HL132825 / HL / NHLBI NIH HHS / United States
R01 HL148050 / HL / NHLBI NIH HHS / United States

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