| Title | Diagnosis of human heritable defects by recombinant DNA methods. |
| Publication Type | Journal Article |
| Year of Publication | 1988 |
| Authors | Caskey, CT, Gibbs, RA, Witkowski, JA, Hejtmancik, JF |
| Journal | Philos Trans R Soc Lond B Biol Sci |
| Volume | 319 |
| Issue | 1194 |
| Pagination | 353-60 |
| Date Published | 1988 Jun 15 |
| ISSN | 0962-8436 |
| Keywords | DNA, Recombinant, Female, Genetic Diseases, Inborn, Genetic Engineering, Genetic Techniques, Humans, Mutation, Pregnancy, Prenatal Diagnosis |
| Abstract | Recombinant DNA methods provide highly sensitive means for the detection of DNA alterations that lead to human disease mutations. In this paper I shall illustrate the approaches currently available and discuss new technologies that show promise of replacing the present methods. Medical diagnosis by means of recombinant DNA methods has an expanding role in clinical medicine.
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| DOI | 10.1098/rstb.1988.0056 |
| Alternate Journal | Philos Trans R Soc Lond B Biol Sci |
| PubMed ID | 2900528 |