Keeping an eye on the fly genome.

TitleKeeping an eye on the fly genome.
Publication TypeJournal Article
Year of Publication2005
AuthorsChen, R, Mardon, G
JournalDev Biol
Volume282
Issue2
Pagination285-93
Date Published2005 Jun 15
ISSN0012-1606
KeywordsAnimals, Cell Differentiation, Computational Biology, Drosophila, Eye, Genome, Genomics, Mutation, Transcription Factors
Abstract

With its unique structure and dynamic development, the Drosophila eye has been a powerful genetic model system for studying molecular mechanisms of cell fate specification and differentiation. Hundreds of genes that function in a complex genetic network controlling this process have been identified during the past two decades. To further advance our understanding of the molecular mechanisms of eye development, it is increasingly important to place the current genetic pathway into a whole-genome perspective. Here, we review emerging technologies and strategies that will help to achieve this goal, including generation of a complete mutant set in Drosophila, genome-wide transcription factor target identification, and systematic studies of gene function aided by computational biology.

DOI10.1016/j.ydbio.2005.04.015
Alternate JournalDev. Biol.
PubMed ID15893305
Grant ListR01 EY011232 / EY / NEI NIH HHS / United States