Why primate models matter.

TitleWhy primate models matter.
Publication TypeJournal Article
Year of Publication2014
AuthorsPhillips, KA, Bales, KL, Capitanio, JP, Conley, A, Czoty, PW, Hart, BA 't, Hopkins, WD, Hu, S-L, Miller, LA, Nader, MA, Nathanielsz, PW, Rogers, J, Shively, CA, Voytko, MLou
JournalAm J Primatol
Volume76
Issue9
Pagination801-27
Date Published2014 Sep
ISSN1098-2345
KeywordsAnimal Experimentation, Animals, Disease Models, Animal, Humans, Primates, United States
Abstract

Research involving nonhuman primates (NHPs) has played a vital role in many of the medical and scientific advances of the past century. NHPs are used because of their similarity to humans in physiology, neuroanatomy, reproduction, development, cognition, and social complexity-yet it is these very similarities that make the use of NHPs in biomedical research a considered decision. As primate researchers, we feel an obligation and responsibility to present the facts concerning why primates are used in various areas of biomedical research. Recent decisions in the United States, including the phasing out of chimpanzees in research by the National Institutes of Health and the pending closure of the New England Primate Research Center, illustrate to us the critical importance of conveying why continued research with primates is needed. Here, we review key areas in biomedicine where primate models have been, and continue to be, essential for advancing fundamental knowledge in biomedical and biological research.

DOI10.1002/ajp.22281
Alternate JournalAm. J. Primatol.
PubMed ID24723482
PubMed Central IDPMC4145602
Grant ListP51 OD011133 / OD / NIH HHS / United States
R01 HL087103 / HL / NHLBI NIH HHS / United States
R01 NS042867 / NS / NINDS NIH HHS / United States
R24 OD011173 / OD / NIH HHS / United States
R24 RR032329 / RR / NCRR NIH HHS / United States