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Marie-Claude Gingras, Ph.D.

Associate Professor, Department of Molecular and Human Genetics

image: Marie-Claude Gingras, Ph.D.Contact information

Other positions

Associate Professor, Michael E. DeBakey Department of Surgery

Associate Professor, Director Nucleic Acid Laboratory, Human Genome Sequencing Center


B.S. Microbiology, University Laval, Faculty of Sciences, Québec, Canada, 1978

Ph.D., Biochemistry, University Laval, Faculty of Medicine, Québec, Canada, 1985

Postdoc, University of Manitoba, Manitoba Institute of Cell Biology, Manitoba, Canada, 1988

Awards and honors

2011: St. Luke’s Episcopal Hospital Roderick Duncan MacDonald Research Foundation Award

2010: St. Luke’s Episcopal Hospital Roderick Duncan MacDonald Research Foundation Award

2008: St. Luke’s Episcopal Hospital Roderick Duncan MacDonald Research Foundation Award

2001: Fleming and Davenport Award

2001: Elsa U. Pardee Foundation Award

2000: Keystone Symposia Award

1994: American Association for Cancer Research Award

1988: National Cancer Institute of Canada Award

1987-1988: Manitoba Health Research Council, Postdoctoral Fellowship

1987: Children's Hospital Research Foundation Inc., Manitoba, Postdoctoral Fellowship

1982: Scientific Exchange Program Québec-Belgique (Belgium), Doctoral Scholarship

1980-1984: Fonds de la Recherche en Santé du Québec (FRSQ), Doctoral Scholarship

1980-1981: Canadian Cancer Research Society, Doctoral Scholarship                

Research interests

Profiling the genome of the pancreaticobiliary and duodenal tumors

The pancreas is the siege of different tumor types originating from different cellular components. The pancreas is connected to the surrounding organs by the pancreatic duct that is fused with the bile duct to form the Ampulla of Vater in the duodenal region. It is a complex environment from which arises some of the deadliest tumors such as the pancreatic ductal adenocarcinoma (PDAC), the 11th most common cancer in the USA but the 4th in fatalities.

The onset and progression of cancer is driven by extensive rearrangement and mutation of the genome. My interest is to detect and characterize the somatic mutation profile of PDAC, pancreatic neuroendocrine tumor, precancerous IPMN, ampullary adenocarcinoma, cholangiocarcinoma, and ductal adenocarcinoma.  By collaborating with local and international institutions to obtain representative amount of tumors and comparing the profile of each of these tumors, my collaborators and I are hoping to identify driver genes that can be targeted for personalized treatment.

Direction of the Nucleic Acid Laboratory (NA Lab)

The first step in the sequencing pipeline is the isolation of nucleic acids of high quality.  As the director of Nucleic Acid laboratory at the BCM-HGSC, I supervise the processing of about 1,600 samples per year from sources as varied as solid tissues and body fluid of different origin from deidentified patients, nonhuman primates and mammals collected by our collaborators.

Treatment of sepsis

Sepsis is caused by an overwhelming immune response induced by hyperactivation of its primary arm, resulting in a deadly excess of inflammation. A few years ago, when studying genes expressed during macrophage differentiation, I discovered TREM1-sv, a splice variant of TREM1 receptor that transmits activation signal to macrophage. To validate the hypothesis that this variant acts as a natural immune regulator in human, the protein was synthesized and injected in two different sepsis mouse models.  TREM1-sv protein prevented hyperactivation of the immune response.  By regulating the immune response, this natural human protein has shown efficacy to prevent death from excess inflammation in preclinical model. We are presently working to validate this new biotherapeutic as a treatment for sepsis.

Other projects

In collaboration with the Sultan Qaboos Universiy of Oman, my Omani collaborators and I are studying and comparing the genetic profile of infant, juvenile, and adult onset glaucoma and metabolic diseases in the Omani population.


Functional annotation of rare gene aberration drivers of pancreatic cancer., Tsang, Yiu Huen, Dogruluk Turgut, Tedeschi Philip M., Wardwell-Ozgo Joanna, Lu Hengyu, Espitia Maribel, Nair Nikitha, Minelli Rosalba, Chong Zechen, Chen Fengju, et al. , Nature communications, 2016, Volume 7, p.10500, (2016) Abstract
Ampullary Cancers Harbor the Tumor Suppressor Gene ELF3 and Exhibit Frequent WNT Dysregulation., Gingras, Marie-Claude, Covington Kyle R., Chang David K., Donehower Lawrence A., Gill Anthony J., Ittmann Michael M., Creighton Chad J., Johns Amber L., Shinbrot Eve, Dewal Ninad, et al. , Cell reports, 2016 Jan 19, (2016) Abstract
Genomic profiling guides the choice of molecular targeted therapy of pancreatic cancer., Frank, Thomas S., Sun Xiaotian, Zhang Yuqing, Yang Jingxuan, Fisher William E., Gingras Marie-Claude, and Li Min , Cancer letters, 2015 Apr 15, (2015) Abstract
Trans-ancestry mutational landscape of hepatocellular carcinoma genomes, Totoki, Yasushi, Tatsuno Kenji, Covington Kyle R., Ueda Hiroki, Creighton Chad J., Kato Mamoru, Tsuji Shingo, Donehower Lawrence A., Slagle Betty L., Nakamura Hiromi, et al. , Nature Genetics, 11/2014, (2014)
PDX-1 is a therapeutic target for pancreatic cancer, insulinoma and islet neoplasia using a novel RNA interference platform., Liu, Shi-He, Rao Donald D., Nemunaitis John, Senzer Neil, Zhou Guisheng, Dawson David, Gingras Marie-Claude, Wang Zhaohui, Gibbs Richard, Norman Michael, et al. , PloS one, 2012, Volume 7, Issue 8, p.e40452, (2012) Abstract
Mutations in KAT6B, encoding a histone acetyltransferase, cause Genitopatellar syndrome., Campeau, Philippe M., Kim Jaeseung C., Lu James T., Schwartzentruber Jeremy A., Abdul-Rahman Omar A., Schlaubitz Silke, Murdock David M., Jiang Ming-Ming, Lammer Edward J., Enns Gregory M., et al. , American journal of human genetics, 2012 Feb 10, Volume 90, Issue 2, p.282-9, (2012) Abstract
Genomic sequencing of key genes in mouse pancreatic cancer cells., Wang, Y., Zhang Y., Yang J., Ni X., Liu S., Li Z., Hodges S. E., Fisher W. E., Brunicardi F. C., Gibbs R. A., et al. , Current molecular medicine, 2012 Mar, Volume 12, Issue 3, p.331-41, (2012) Abstract
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes., Biankin, Andrew V., Waddell Nicola, Kassahn Karin S., Gingras Marie-Claude, Muthuswamy Lakshmi B., Johns Amber L., Miller David K., Wilson Peter J., Patch Ann-Marie, Wu Jianmin, et al. , Nature, 2012 Nov 15, Volume 491, Issue 7424, p.399-405, (2012) Abstract
New Found Association Between Mutated Tumor Suppressive Gene And Non-Hepatitis C Hepatocellular Carcinoma, Nguyen, NT, Harring TR, Drummond J., Chang K., Gingras M., Wheeler D. A., O'Mahoney CA, and Goss JA , Journal of Surgical Research, Volume 165, Number 2, p.177, (2011)
Building a comprehensive genomic program for hepatocellular carcinoma., Harring, Theresa R., Guiteau Jacfranz J., Nguyen Thao N. T., Cotton Ron T., Gingras Marie-Claude, Wheeler David A., O'Mahony Christine A., Gibbs Richard A., Brunicardi Charles F., and Goss John A. , World journal of surgery, 2011 Aug, Volume 35, Issue 8, p.1746-50, (2011) Abstract
A primer on a hepatocellular carcinoma bioresource bank using the cancer genome atlas guidelines: practical issues and pitfalls., Nguyen, Thao N. T., Cotton Ron T., Harring Theresa R., Guiteau Jacfranz J., Gingras Marie-Claude, Wheeler David A., O'Mahony Christine A., Gibbs Richard A., Brunicardi Charles F., and Goss John A. , World journal of surgery, 2011 Aug, Volume 35, Issue 8, p.1732-7, (2011) Abstract
The hypofunctional effect of P335L single nucleotide polymorphism on SSTR5 function., Zhou, Guisheng, Gingras Marie-Claude, Liu Shi-He, Li Donghui, Li Zhijun, Catania Robbi L., Stehling Kelly M., Li Min, Paganelli Giovanni, Gibbs Richard A., et al. , World journal of surgery, 2011 Aug, Volume 35, Issue 8, p.1715-24, (2011) Abstract
SSTR5 P335L monoclonal antibody differentiates pancreatic neuroendocrine neuroplasms with different SSTR5 genotypes., Zhou, Guisheng, Gingras Marie-Claude, Liu Shi-He, Sanchez Robbi, Edwards Dean, Dawson David, Christensen Kurt, Paganelli Giovanni, Gibbs Richard, Fisher William, et al. , Surgery, 2011 Dec, Volume 150, Issue 6, p.1136-42, (2011) Abstract
PDX-1: demonstration of oncogenic properties in pancreatic cancer., Liu, Shi-He, Patel Sanjeet, Gingras Marie-Claude, Nemunaitis John, Zhou Guisheng, Chen Changyi, Li Min, Fisher William, Gibbs Richard, and Brunicardi Charles F. , Cancer, 2011 Feb 15, Volume 117, Issue 4, p.723-33, (2011) Abstract
Association between somatostatin receptor 5 gene polymorphisms and pancreatic cancer risk and survival., Li, Donghui, Tanaka Motofumi, Brunicardi Charles F., Fisher William E., Gibbs Richard A., and Gingras Marie-Claude , Cancer, 2011 Jul 1, Volume 117, Issue 13, p.2863-72, (2011) Abstract
Whole-genome sequencing for optimized patient management., Bainbridge, Matthew N., Wiszniewski Wojciech, Murdock David R., Friedman Jennifer, Gonzaga-Jauregui Claudia, Newsham Irene, Reid Jeffrey G., Fink John K., Morgan Margaret B., Gingras Marie-Claude, et al. , Science translational medicine, 2011 Jun 15, Volume 3, Issue 87, p.87re3, (2011) Abstract
PERSONALIZED GENOMICS IN THE 21ST CENTURY: IMPLICATIONS FOR NURSING RESEARCH WITH CHILDREN AND FAMILIES, SYPK, Shiao, and Gingras M. C. , Southern Online Journal of Nursing Research, 09/2010, Volume 10, Issue 3, (2010) Abstract
Microarray analysis of somatostatin receptor 5-regulated gene expression profiles in murine pancreas., Patel, Sanjeet G., Zhou Guisheng, Liu Shi-He, Li Min, Jeong Jae-Wook, DeMayo Francesco J., Gingras Marie-Claude, Gibbs Richard A., Fisher William E., and Brunicardi Charles F. , World journal of surgery, 2009 Apr, Volume 33, Issue 4, p.630-7, (2009) Abstract
Developing a tissue resource to characterize the genome of pancreatic cancer., Voidonikolas, Georgios, Gingras Marie-Claude, Hodges Sally, McGuire Amy L., Chen Changyi, Gibbs Richard A., Brunicardi Charles F., and Fisher William E. , World journal of surgery, 2009 Apr, Volume 33, Issue 4, p.723-31, (2009) Abstract
Basic principles and technologies for deciphering the genetic map of cancer., Voidonikolas, Georgios, Kreml Stephanie S., Chen Changyi, Fisher William E., Brunicardi Charles F., Gibbs Richard A., and Gingras Marie-Claude , World journal of surgery, 2009 Apr, Volume 33, Issue 4, p.615-29, (2009) Abstract
Sequencing the full-length of the phosphatase and tensin homolog (PTEN) gene in hepatocellular carcinoma (HCC) using the 454 GS20 and Illumina GA DNA sequencing platforms., Rodriguez, Joel A., Guiteau Jacfranz J., Nazareth Lynne, Reid Jeff G., Goss John A., Gibbs Richard A., and Gingras Marie-Claude , World journal of surgery, 2009 Apr, Volume 33, Issue 4, p.647-52, (2009) Abstract
Single nucleotide polymorphism in RECQL and survival in resectable pancreatic adenocarcinoma., Cotton, Ronald T., Li Donghui, Scherer Steven E., Muzny Donna M., Hodges Sally E., Catania Robbi L., Witkiewicz Agnieszka K., Brody Jonathan R., Kennedy Eugene P., Yeo Charles J., et al. , HPB : the official journal of the International Hepato Pancreato Biliary Association, 2009 Aug, Volume 11, Issue 5, p.435-44, (2009) Abstract
PDX-1 acts as a potential molecular target for treatment of human pancreatic cancer., Liu, Shihe, Ballian Nikiforos, Belaguli Narasimhaswamy S., Patel Sanjeet, Li Min, Templeton Nancy Smyth, Gingras Marie-Claude, Gibbs Richard, Fisher William, and Brunicardi Charles F. , Pancreas, 2008 Aug, Volume 37, Issue 2, p.210-20, (2008) Abstract
High-throughput gene expression profiling--a work-in-progress with great potential for proteomics., Roussel, Eugene, and Gingras Marie-Claude , Current opinion in drug discovery & development, 2006 May, Volume 9, Issue 3, p.332-8, (2006) Abstract
Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia., Al-Lamki, Zakia, Wali Yasser A., Wasifuddin Shah M., Zachariah Mathew, Al-Mjeni Rayhanah, Li Changping, Muralitharan Shanmugakonar, Al-Kharusi Khalsa, Gunaratne Preethi, Peterson Leif, et al. , Pediatric hematology and oncology, 2005 Oct-Nov, Volume 22, Issue 7, p.629-43, (2005) Abstract

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