David Murdock, M.D., F.A.C.M.G.

Assistant Professor, Molecular and Human Genetics
Assistant Director, Human Genome Sequencing Center Clinical Laboratory

David Murdock, M.D., F.A.C.M.GContact

david.murdock@bcm.edu

Education

B.S. from Rice University
Houston, Texas, United States
Bioengineering
M.D. from Baylor College of Medicine
Houston, Texas, United States
Postdoctoral Fellowship at Baylor College of Medicine
Houston, Texas, United States
Human Genome Sequencing Center
Residency at Louisiana State University Health Sciences Center
Shreveport, Louisiana, United States
Internal Medicine
Clinical Fellowship at the National Institutes of Health
Bethesda, Maryland, United States
Clinical Genetics, NIH-Johns Hopkins Consortium
Fellowship at the National Institutes of Health
Bethesda, Maryland, United States
Molecular Genetics

Research interests

My clinical and research interests involve connective tissue disorders such as Marfan syndrome and Loeys-Dietz syndrome, conditions that lead to aortic aneurysms and dissections. I am particularly interested in identifying new genes associated with such aortopathies and exploring the mechanisms of genetically-mediated aneurysm development. I also study Xia-Gibbs syndrome, a developmental disorder due to truncating mutations in the AHDC1 gene. The goal of these research efforts is to develop new therapies to improve outcomes. Among the tools I use are whole exome and genome sequencing as well as RNAseq.

As a member of the adult genetics team I diagnose and manage adults with a variety of genetic conditions (e.g., cancer). I am also the assistant director of the HGSC CAP/CLIA clinical lab where I perform analysis, interpretation, and reporting of sequencing data. I am committed to the growing field of personalized medicine through the eMERGE and BCM Cardiovascular Disease Genetics efforts. Lastly, I am dedicated to education and enjoy teaching about principles of genetics.

Publications

Jiang Y, Wangler MF, McGuire AL, et al. The phenotypic spectrum of Xia-Gibbs syndrome. Am J Med Genet A. 2018;176(6):1315-1326. doi:10.1002/ajmg.a.38699.

Murdock DR, Salit J, Stoffel M, et al. Longitudinal study shows increasing obesity and hyperglycemia in micronesia. Obesity (Silver Spring). 2013;21(9):E421-7. doi:10.1002/oby.20041.