David Murdock, M.D., F.A.C.M.G.

Assistant Professor, Molecular and Human Genetics
Assistant Director, Human Genome Sequencing Center Clinical Laboratory

David Murdock, M.D., F.A.C.M.GContact

david.murdock@bcm.edu

Education

B.S. from Rice University
Houston, Texas, United States
Bioengineering
M.D. from Baylor College of Medicine
Houston, Texas, United States
Postdoctoral Fellowship at Baylor College of Medicine
Houston, Texas, United States
Human Genome Sequencing Center
Residency at Louisiana State University Health Sciences Center
Shreveport, Louisiana, United States
Internal Medicine
Clinical Fellowship at the National Institutes of Health
Bethesda, Maryland, United States
Clinical Genetics, NIH-Johns Hopkins Consortium
Fellowship at the National Institutes of Health
Bethesda, Maryland, United States
Molecular Genetics

Research interests

My clinical and research interests involve connective tissue disorders such as Marfan syndrome and Loeys-Dietz syndrome, conditions that lead to aortic aneurysms and dissections. I am particularly interested in identifying new genes associated with such aortopathies and exploring the mechanisms of genetically-mediated aneurysm development. I also study Xia-Gibbs syndrome, a developmental disorder due to truncating mutations in the AHDC1 gene. The goal of these research efforts is to develop new therapies to improve outcomes. Among the tools I use are whole exome and genome sequencing as well as RNAseq.

As a member of the adult genetics team I diagnose and manage adults with a variety of genetic conditions (e.g., cancer). I am also the assistant director of the HGSC CAP/CLIA clinical lab where I perform analysis, interpretation, and reporting of sequencing data. I am committed to the growing field of personalized medicine through the eMERGE and BCM Cardiovascular Disease Genetics efforts. Lastly, I am dedicated to education and enjoy teaching about principles of genetics.

Publications

2024
Hu J, Korchina V, Zouk H, Harden MV, Murdock DR, Macbeth A, et al.. Genetic sex validation for sample tracking in next-generation sequencing clinical testing. BMC Res Notes. 2024;17(1):62.

2022
Smith HStevens, Sanchez CE, Maag R, Buentello A, Murdock DR, Metcalf GA, et al.. Patient and Clinician Perceptions of Precision Cardiology Care: Findings From the HeartCare Study. Circ Genom Precis Med. 2022;15(6):e003605.

Dai H, Zhu W, Yuan B, Walley N, Schoch K, Jiang Y-H, et al.. A recurrent single-exon deletion in TBCK might be under-recognized in patients with infantile hypotonia and psychomotor delay. Hum Mutat. 2022;43(12):1816-1823.

Chander V, Mahmoud M, Hu J, Dardas Z, Grochowski CM, Dawood M, et al.. Long read sequencing and expression studies of AHDC1 deletions in Xia-Gibbs syndrome reveal a novel genetic regulatory mechanism. Hum Mutat. 2022;43(12):2033-2053.

Harrison SM, Austin-Tse CA, Kim S, Lebo M, Leon A, Murdock DR, et al.. Harmonizing variant classification for return of results in the All of Us Research Program. Hum Mutat. 2022;43(8):1114-1121.

Austin-Tse CA, Jobanputra V, Perry DL, Bick D, Taft RJ, Venner E, et al.. Best practices for the interpretation and reporting of clinical whole genome sequencing. NPJ Genom Med. 2022;7(1):27.

2021
Marom R, Burrage LC, Venditti R, Clément A, Blanco-Sánchez B, Jain M, et al.. COPB2 loss of function causes a coatopathy with osteoporosis and developmental delay. Am J Hum Genet. 2021;108(9):1710-1724.

Khayat MM, Hu J, Jiang Y, Li H, Chander V, Dawood M, et al.. missense mutations in Xia-Gibbs syndrome. HGG Adv. 2021;2(4).

Venner E, Yi V, Murdock DR, Kalla SE, Wu T-J, Sabo A, et al.. Neptune: an environment for the delivery of genomic medicine. Genet Med. 2021;23(10):1838-1846.

Tosur M, Soler-Alfonso C, Chan KM, Khayat MM, Jhangiani SN, Meng Q, et al.. Exome sequencing in children with clinically suspected maturity-onset diabetes of the young. Pediatr Diabetes. 2021;22(7):960-968.

Khayat MM, Li H, Chander V, Hu J, Hansen AW, Li S, et al.. Phenotypic and protein localization heterogeneity associated with AHDC1 pathogenic protein-truncating alleles in Xia-Gibbs syndrome. Hum Mutat. 2021;42(5):577-591.

Murdock DR, Venner E, Muzny DM, Metcalf GA, Murugan M, Hadley TD, et al.. Genetic testing in ambulatory cardiology clinics reveals high rate of findings with clinical management implications. Genet Med. 2021;23(12):2404-2414.

2020
Barish S, Barakat TStefan, Michel BC, Mashtalir N, Phillips JB, Valencia AM, et al.. BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms. Am J Hum Genet. 2020;107(6):1096-1112.

2018
Jiang Y, Wangler MF, McGuire AL, Lupski JR, Posey JE, Khayat MM, et al.. The phenotypic spectrum of Xia-Gibbs syndrome. Am J Med Genet A. 2018;176(6):1315-1326.

2013
Murdock DR, Salit J, Stoffel M, Friedman JM, Pe'er I, Breslow JL, et al.. Longitudinal study shows increasing obesity and hyperglycemia in micronesia. Obesity (Silver Spring). 2013;21(9):E421-7.

2011
Murdock DR, Clark GD, Bainbridge MN, Newsham I, Wu Y-Q, Muzny DM, et al.. Whole-exome sequencing identifies compound heterozygous mutations in WDR62 in siblings with recurrent polymicrogyria. Am J Med Genet A. 2011;155A(9):2071-7.

Bainbridge MN, Wiszniewski W, Murdock DR, Friedman J, Gonzaga-Jauregui C, Newsham I, et al.. Whole-genome sequencing for optimized patient management. Sci Transl Med. 2011;3(87):87re3.